Thermal Aggregation of Recombinant Protective Antigen: Aggregate Morphology and Growth Rate
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چکیده
منابع مشابه
Thermal Aggregation of Recombinant Protective Antigen: Aggregate Morphology and Growth Rate
The thermal aggregation of the biopharmaceutical protein recombinant protective antigen (rPA) has been explored, and the associated kinetics and thermodynamic parameters have been extracted using optical and environmental scanning electron microscopies (ESEMs) and ultraviolet light scattering spectroscopy (UV-LSS). Visual observations and turbidity measurements provided an overall picture of th...
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A semi-batch crystallization system is used to determine growth kinetics and morphology of barium carbonate crystals, under a constant pH value and constant temperature in the various relative supersaturations. Results show that crystal growth rate satisfies a first-order kinetic expression at high relative supersaturation, while at relative supersaturation values lower than 3, the k...
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Background: Hepatitis delta virus (HDV) is a subviral human pathogen that exploits host RNA editing activity to produce two essential forms of the sole viral protein, hepatitis delta antigen (HDAg). Editing at the amber/W site of HDV antigenomic RNA leads to the production of the large form (L-HDAg), which is required for RNA packaging. Methods: In this study, PCR-based site-directed mutagen...
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15 صفحه اولGeneration and Characterization of Human Monoclonal Antibodies Targeting Anthrax Protective Antigen following Vaccination with a Recombinant Protective Antigen Vaccine.
The anthrax protective antigen (PA) is the central component of the three-part anthrax toxin, and it is the primary immunogenic component in the approved AVA anthrax vaccine and the "next-generation" recombinant PA (rPA) anthrax vaccines. Animal models have indicated that PA-specific antibodies (AB) are sufficient to protect against infection with Bacillus anthracis. In this study, we investiga...
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ژورنال
عنوان ژورنال: Journal of Biophysics
سال: 2013
ISSN: 1687-8000,1687-8019
DOI: 10.1155/2013/751091